A2408

Sigma

 

S-(5′-Adenosyl)-L-methionine p-toluenesulfonate salt

from yeast (L-methionine enriched), ≥80% (HPLC), ≥80% (spectrophotometric assay)

Synonym:AdoMet, SAM p-toluenesulfonate salt
CAS Number:17176-17-9
Linear Formula:C15H22N6O5S ยท xC7H8O3S
Molecular Weight:398.44 (free base basis)
MDL number:MFCD00063498
PubChem Substance ID:24890653

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Description

Analysis NotePurity based on UV and HPLC.
Biochem/physiol ActionsS-(5′-Adenosyl)-L-methionine (SAM) is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
CautionThis material is unstable at room temperature.
 Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Properties

biological source from yeast (L-methionine enriched)
assay≥80% (HPLC)
 ≥80% (spectrophotometric assay)
compositionp-Toluenesulfonate content, 2-4 mol/mol
solubilityH2O: 100 mg/mL
shipped indry ice
storage temp.−20°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany3

References

referenceMato, J.M., S-Adenosylmethionine: a control switch that regulates liver function. FASEB J. 16, 15-26, (2002)
 Villar-Garea, A., and Esteller, M., DNA demethylating agents and chromatin-remodelling drugs: which, how and why?. Curr. Drug Metab. 4, 11-31, (2003)